| (+)-MethylCembra-1,3,7,11-tetraene-16-carboxynate的不对称合成研究 |
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| 引用本文： | 孙彬,梅天胜,刘佐胜,李裕林,李瀛,彭立增.(+)-MethylCembra-1,3,7,11-tetraene-16-carboxynate的不对称合成研究[J].高等学校化学学报,2005,26(5):880-882. |
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| 作者姓名： | 孙彬 梅天胜 刘佐胜 李裕林 李瀛 彭立增 |
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| 作者单位： | 1. 兰州大学功能有机化学国家重点实验室, 兰州730000;
2. 山东鲁南制药股份有限公司, 临沂276003 |
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| 基金项目： | 国家自然科学基金;高等学校博士学科点专项科研项目 |
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| 摘 要： | The first asymmetric synthesis of ( )-methyl cembra-1,3,7,11-tetraene-16-carboxynate, a naturally occurring cembrane-type macrocyclic diterpene isolated from Sinularia mayi, was achieved via general approach by employing an intramolecular McMurry coupling and Sharpless asymmetric epoxidation as the key steps from readily available starting materials. The synthesis presented here verifies that the absolute configuration of compound 1 was assumed as 15R.
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| 关 键 词： | 西松烷型大环二萜 天然产物 不对称合成 |
| 文章编号： | 0251-0790(2005)05-0880-03 |
| 收稿时间： | 2004-11-01 |
Asymmetric Synthesis of Natural Macrocyclic Diterpene(+)-Methyl Cembra-1,3,7,11-tetraene-16-carboxynate |
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| SUN Bin,MEI Tian-sheng,LIU Zuo-Sheng,LI Yu-Lin,LI Ying,PENG Li-Zeng.Asymmetric Synthesis of Natural Macrocyclic Diterpene(+)-Methyl Cembra-1,3,7,11-tetraene-16-carboxynate[J].Chemical Research In Chinese Universities,2005,26(5):880-882. |
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| Authors: | SUN Bin MEI Tian-sheng LIU Zuo-Sheng LI Yu-Lin LI Ying PENG Li-Zeng |
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| Institution: | 1. National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China;
2. Lunan Pharmaceutical Co., Ltd., Linyi 276003, China |
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| Abstract: | The first asymmetric synthesis of (+)-methyl cembra-1,3,7,11-tetraene-16-carboxynate, a naturally occurring cembrane-type macrocyclic diterpene isolated from Sinularia mayi, was achieved via general approach by employing an intramolecular McMurry coupling and Sharpless asymmetric epoxidation as the key steps from readily available starting materials. The synthesis presented here verifies that the absolute configuration of compound 1 was assumed as 15R. |
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| Keywords: | Cembrane-type macrocyclic diterpene Natural product Asymmetric synthesis |
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