Chemical modification of the alkaloid 2,3-tetramethylene-3,4-dihydroquinazol-4-one |
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| Authors: | Kh. M. Shakhidoyatov Z. U. Samarov N. I. Mukarramov M. G. Levkovich N. D. Abdullaev B. Tashkhodzhaev Yasser Barakat B. A. Urakov |
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| Affiliation: | (1) S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent |
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| Abstract: | The 1,2-dihydro derivative of 2,3-tetramethylene-3,4-dihydroquinazol-4-one was produced by reduction and characterized using NMR spectra. 1-Acyl-1,2,3,4-tetrahydroquinazol-4-ones and ureas were synthesized by acylation of 2,3-tetramethylene-1,2,3,4-tetrahydroquinazol-4-one with acid chlorides and arylisocyanates, respectively. The molecular structures of 1-acetyl-and-m-chlorophenylaminocarbonyl-2,3-tetramethylene-1,2,3,4-tetrahydroquinazol-4-ones were established using x-ray structure analyses. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 364–370, July–August, 2007. |
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| Keywords: | 2,3-tetramethylene-2,3-dihydro(1,2,3,4-tetrahydro)quinazol-4-one alkaloids PMR and 13C NMR spectroscopy XSA acylation reduction nucleophilic substitution |
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