A water-soluble, small molecular fluorescent sensor with femtomolar sensitivity for zinc ion |
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| Authors: | Wang Huan-Huan Gan Quan Wang Xiao-Jun Xue Lin Liu Sheng-Hua Jiang Hua |
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| Affiliation: | Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080 P. R. China. |
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| Abstract: | A water-soluble fluorescent sensor, 1, based on the quinoline platform, demonstrates femtomolar sensitivity for zinc ion with a 14-fold enhanced quantum yield upon chelation to zinc ion and also exhibits high selectivity to zinc ion over other physiological relevant divalent metals in the presence of EDTA. X-ray crystal structure of zinc complex reveals that an acetic carboxylic group participates in coordination, which significantly enhances the affinity of 1 for zinc ion. |
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