Sunflower-Like Nanostructure with Built-In Hotspots for Alpha-Fetoprotein Detection |
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| Authors: | Xiaoyu Zhao Aonan Zhu Yaxin Wang Yongjun Zhang Xiaolong Zhang |
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| Affiliation: | 1.School of Material and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China; (X.Z.); (Y.W.);2.College of Chemistry, Nankai University, Tianjin 300071, China;3.College of Physics, Jilin Normal University, Changchun 130103, China; |
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| Abstract: | In the present study, a sunflower-like nanostructure array composed of a series of synaptic nanoparticles and nanospheres was manufactured through an efficient and low-cost colloidal lithography technique. The primary electromagnetic field contribution generated by the synaptic nanoparticles of the surface array structures was also determined by a finite-difference time-domain software to simulate the hotspots. This structure exhibited high repeatability and excellent sensitivity; hence, it was used as a surface-enhanced Raman spectroscopy (SERS) active substrate to achieve a rapid detection of ultra-low concentrations of Alpha-fetoprotein (AFP). This study demonstrates the design of a plasmonic structure with strong electromagnetic coupling, which can be used for the rapid detection of AFP concentration in clinical medicine. |
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| Keywords: | LSPR SERS alpha-fetoprotein |
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