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HPTLC Determination of Cefpodoxime Proxetil in Formulations
Authors:Abhijit A Date  Mangal S Nagarsenker
Institution:1. Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E.), Mumbai, 400098, India
Abstract:An HPTLC method has been developed that coelutes both the isomers of cefpodoxime proxetil (CFP). CFP was chromatographed on a silica gel 60 F254 TLC plate using toluene:acetonitrile (6:4) as a mobile phase and was quantified at 234 nm. The method was validated with respect to linearity, accuracy, precision and specificity. The limit of detection and limit of quantification for CFP were found to be 0.150 and 0.4 μg spot?1, respectively. The proposed method was successfully used to determine the amount of CFP present in the marketed tablets and self-nanoemulsifying systems.
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