Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of (+/-)-flustramines A and C |
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| Authors: | Fuchs James R Funk Raymond L |
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| Affiliation: | Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA. |
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| Abstract: | A variety of 3,3-disubstituted 2-indolinones have been prepared by treatment of 3-bromo-3-alkyl-2-indolinones with dienophiles/nucleophiles in the presence of cesium carbonate. Application of this general strategy has facilitated the total syntheses of the reverse prenylated marine natural products (+/-)-flustramine A and (+/-)-flustramine C. [Structure: see text] |
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