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Total synthesis of gambierol |
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| Authors: | Kadota Isao Takamura Hiroyoshi Sato Kumi Ohno Akio Matsuda Kumiko Yamamoto Yoshinori |
| Affiliation: | Research Center for Sustainable Materials Engineering, Institute of Multidisciplinary Research for Advanced Materials, and Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. |
| Abstract: | The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of alpha-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain. |
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