A highly sensitive sensor of paracetamol based on zinc-layered hydroxide-L-phenylalanate-modified multiwalled carbon nanotube paste electrode |
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| Authors: | Mohamad Syahrizal Ahmad Illyas Md Isa Norhayati Hashim Suyanta M. Si Mohamad Idris Saidin |
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| Affiliation: | 1.Nanotechnology Research Centre, Faculty of Science and Mathematics,Sultan Idris Education University,Tanjung Malim,Malaysia;2.Department of Chemistry, Faculty of Science and Mathematics,Sultan Idris Education University,Tanjung Malim,Malaysia;3.Department of Chemistry Education, Faculty of Mathematics and Natural Science,Yogyakarta State University,Yogyakarta,Indonesia;4.Advanced Analytical Services Laboratory,MIMOS Bhd., Technology Park of Malaysia,Kuala Lumpur,Malaysia |
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| Abstract: | A new zinc-layered hydroxide-L-phenylalanate (ZLH-LP)-modified multiwalled carbon nanotube (MWCNT) was prepared as a new material of paste electrode for the detection of paracetamol (PCM) in 1.0?×?10?1 M phosphate buffer solution and at pH 7.5. The electrochemical characterization of the MWCNTs/ZLH-LP paste electrode was characterized by square wave voltammetry, electrochemical impedance spectroscopy, and cyclic voltammetry while the morphology properties of the MWCNTs, ZLH-LP, and MWCNTs/ZLH-LP were investigated using transmission electron microscopy and scanning electron microscopy. Under optimized conditions, the MWCNTs/ZLH-LP paste electrode demonstrated an excellent electrocatalytic activity towards oxidation of PCM in the linear responses’ ranges from 7.0?×?10?7 M to 1.0?×?10?4 M (correlation coefficient, 0.996) with the limit of detection obtained at 8.3?×?10?8 M. As a conclusion, the MWCNTs/ZLH-LP paste electrode revealed good repeatability, reproducibility, and stability, and was found to be applicable for use in pharmaceutical tablet samples. |
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