Chemical composition and antibacterial activity of Lavandula coronopifolia essential oil against antibiotic-resistant bacteria |
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| Authors: | L. Ait Said K. Zahlane I. Ghalbane S. El Messoussi C. Cavaleiro |
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| Affiliation: | 1. Laboratory of Molecular and Ecophysiology Modeling, Faculty of Sciences-Semlalia, Cadi Ayyad University, Marrakech, Morocco;2. Laboratory of Applied Organic Chemistry, Cadi Ayyad University, Faculty of Sciences-Semlalia, Marrakech, Morocco;3. Laboratory of Medical Analysis, Ibn Tofail Hospital, CHU Mohamed IV, Marrakech, Morocco;4. Faculdade de Farmácia, Centro de Estudos Farmacêuticos, Universidade de Coimbra, Coimbra3000-548, Portugal |
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| Abstract: | The aim of this study was to analyse the composition of the essential oil (EO) of Lavandula coronopifolia from Morocco and to evaluate its in vitro antibacterial activity against antibiotic-resistant bacteria isolated from clinical infections. The antimicrobial activity was assessed by a broth micro-well dilution method using multiresistant clinical isolates of 11 pathogenic bacteria: Klebsiella pneumoniae subsp. pneumoniae, Klebsiella ornithinolytica, Escherichia coli, Enterobacter cloacae, Enterobacter aerogenes, Providencia rettgeri, Citrobacter freundii, Hafnia alvei, Salmonella spp., Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus. The main compounds of the oil were carvacrol (48.9%), E-caryophyllene (10.8%) and caryophyllene oxide (7.7%). The oil showed activity against all tested strains with minimal inhibitory concentration (MIC) values ranging between 1% and 4%. For most of the strains, the MIC value was equivalent to the minimal bactericidal concentration value, indicating a clear bactericidal effect of L. coronopifolia EO. |
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| Keywords: | Lavandula coronopifolia essential oil antibacterial activity multiresistant bacteria |
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