Chemical composition and antioxidant activity of a polar extract of Thymelaea microphylla Coss. et Dur. |
| |
| Authors: | Khawla Kerbab Tarak Mekhelfi Lahcene Zaiter Samir Benayache Fadila Benayache Patrizia Picerno |
| |
| Institution: | 1. Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, Route de A?n El Bey, Constantine, Algérie;2. Dipartimento di Farmacia, Università degli Studi di Salerno, via Giovanni Paolo II 132, 84084Fisciano (SA), Italy |
| |
| Abstract: | Thymelaea microphylla Coss. et Dur. (Thymelaeaceae) is a rare medicinal plant endemic to Algeria. In order to continue our studies on this species, herein we report the isolation and characterisation of 20 compounds from a hydroalcoholic extract (EtOH–H2O 7:3) of the aerial parts. They include monoterpene glucosides (1–3), phenolic acid derivatives (4, 8 and 9), phenylpropanoid glucosides (5 and 6), flavonoids (7, 10 and 11), a benzyl alcohol glucoside (12), ionol glucosides (13–16), lignans (17–19) and a bis-coumarin (20). All the structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, as well as ESI-MS analysis. Moreover, the extract of T. microphylla showed a significant and concentration-dependent free radical-scavenging activity in vitro, correlated to the presence of phenolic and chlorogenic acid derivatives (8, 9 and 4). |
| |
| Keywords: | Thymelaea microphylla polyphenols lignans ionol glucosides monoterpenes bis-coumarin free radical-scavenging activity |
|
|
