Antibacterial and antioxidant constituents of Acalypha wilkesiana |
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| Authors: | Chinedu P Anokwuru Annamaria Sinisi Amidou Samie Orazio Taglialatela-Scafati |
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| Institution: | 1. Department of Basic Science, School of Science and Technology, Babcock University, Ilisan Remo, Nigeria;2. Department of Chemistry, School of Mathematical and Natural Sciences, University of Venda, Thohoyandou, South Africa;3. Department of Pharmacy, University of Naples Federico II, Via Montesano 49, 80131 Naples, Italy;4. Department of Microbiology, School of Mathematical and Natural Sciences, University of Venda, Thohoyandou, South Africa |
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| Abstract: | This study was aimed at characterising the secondary metabolites responsible for antibacterial and antioxidant activities of Acalypha wilkesiana. Purification of the defatted methanol leaves extract was guided by the DPPH free radical scavenging assay as well as by evaluation of the antibacterial activity against four bacterial strains. As a result, geraniin, corilagin, quadrangularic acid M and shikimic acid were purified and isolated. Shikimic acid, reported for the first time from this plant, proved to be the major metabolite of the extract. All the four isolated compounds showed bactericidal activity against extended spectrum beta-lactamase-producing Klebsiella pneumoniae (700603), while corilagin was the single compound to exhibit antioxidant activity (IC50 53 μg/mL). |
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| Keywords: | geraniin corilagin quadrangularic acid M shikimic acid Acalypha wilkesiana |
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