Dhasingreoside: new flavonoid from the stems and leaves of Gaultheria fragrantissima |
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| Authors: | Fei Cong Khem Raj Joshi Hari Prasad Devkota Takashi Watanabe |
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| Affiliation: | 1. Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo ku, Kumamoto 862-0973, Japan;2. Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto University, Kumamoto, Japan;3. Faculty of Science and Technology, School of Health and Allied Sciences, Pokhara University, P.O. Box 427 Lekhnath, Kaski, Nepal;4. Faculty of Science and Technology, School of Health and Allied Sciences, Pokhara University, P.O. Box 427 Lekhnath, Kaski, Nepal;5. Research Organization for Regional Alliances, Kochi University of Technology, 185 Miyanokuchi, Tosayamada, Kami City, Kochi 782-0003, Japan |
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| Abstract: | A new flavonoid, dhasingreoside (1) and seven known compounds, quercetin 3-O-β-d-galacturonopyranoside (2), quercetin 3-O-β-d-galactopyranoside (3), quercetin 3-O-β-d-glucuronopyranoside (4), quercetin 3-O-α-l-rhamnopyranoside (5), (–)-epicatechin (6), salicylic acid (7) and gaultherin (8), have been isolated from the shade-dried stems and leaves of Gaultheria fragrantissima, commonly known as ‘Dhasingre’ in Nepal. The structures were elucidated on the basis of physical, chemical and spectroscopic methods. Among known compounds, five compounds (3–6 and 8) were isolated for the first time from G. fragrantissima. In vitro antioxidant activity of all the isolated compounds was evaluated by 1,1-diphenyl-2-picrylhydrazyl free radical-scavenging assay. Dhasingreoside (1) and other compounds (2–6) showed significant free radical-scavenging activity. |
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| Keywords: | Gaultheria fragrantissima dhasingreoside Dhasingre in vitro DPPH |
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