Evaluation of hepatoprotective activity of aqueous extracts of leaves of Basella alba in albino rats |
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Authors: | Saibal Das Anand Ramasamy Somnath Mondal |
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Institution: | 1. Nalmuri Block Primary Health Centre, Block: Bhangore-I, South 24, Parganas, West Bengal, India;2. Department of Pharmacology, Christian Medical College, Vellore, India;3. Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India |
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Abstract: | This study was done to evaluate possible hepatoprotective effects of aqueous leaf extracts of Basella alba in comparison with silymarin in paracetamol-induced hepatotoxicity in albino rats. Six groups of six albino rats each received orally for 6 weeks, vehicle, paracetamol (2 g/kg/day), paracetamol (2 g/kg/day) plus silymarin (50 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (60 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (80 mg/kg/day) and paracetamol (2 g/kg/day) plus B. alba extract (100 mg/kg/day). Hepatoprotective effect was evaluated by comparing serum bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, proteins, alkaline phosphatase and liver histopathology. Results were represented as mean ± SEM. One-way ANOVA was done followed by post hoc Tukey's test with a highly significance level of P < 0.001. Aqueous leaf extracts of B. alba 100 mg/kg/day orally had significant hepatoprotective effect in paracetamol-induced hepatotoxicity in albino rats. The results were well comparable and even in some respects superior to standard drug silymarin. |
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Keywords: | Basella alba silymarin paracetamol hepatoprotective effects hepatotoxicity |
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