Geissoschizine methyl ether N-oxide,a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla |
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| Authors: | Wei-Wei Jiang Jia Su Xing-De Wu Juan He Li-Yan Peng Xiao Cheng |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;2. University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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| Abstract: | Geissoschizine methyl ether N-oxide, a new oxindole alkaloid, along with 14 known alkaloids, was isolated from the aerial part of Uncaria rhynchophylla. Their structures were identified by comprehensive spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that the new compound exhibited anti-AChE activity with IC50 value of 23.4 μM. |
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| Keywords: | Uncaria rhynchophylla Rubiaceae alkaloids geissoschizine methyl ether N-oxide anti-AChE activity |
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