Hepatoprotective and neuroprotective tocopherol analogues isolated from the peels of Citrus unshiu Marcovich |
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| Authors: | KH Seo DY Lee DS Lee HC Kang HS Kim YC Kim |
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| Institution: | 1. Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin, Republic of Korea;2. Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, Republic of Korea;3. College of Pharmacy, Wonkwang University, Iksan, Republic of Korea;4. R&5. D Center, GFC Co., Ltd., Yongin, Republic of Korea;6. SEOULCOSMETICS, Co., Ltd, R&7. D Center, Incheon, Republic of Korea |
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| Abstract: | Three tocopherol analogues methoxytocopherol (1), α-tocopherol (2) and γ-tocopherol (3) were isolated from the peels of Citrus unshiu Marcovich. The protective effects of the isolated compounds against tert-butyl hydroperoxide-induced hepatotoxicity in human liver-derived HepG2 cells and glutamate-induced oxidative stress in HT22-immortalised hippocampal cells were evaluated. Compounds 1–3 were significantly protective in HepG2 cells with EC50 values of 21.22 ± 2.01, 25.21 ± 2.11 and 25.25 ± 1.21 μM, respectively, and in HT22 cells, compounds 1–3 had EC50 values of 20.62 ± 1.36, 6.44 ± 1.65 and 9.52 ± 1.54 μM, respectively. |
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| Keywords: | Citrus unshiu hepatoprotective HepG2 HT22 methoxytocopherol neuroprotective tocopherol |
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