Bioactive DOPA melanin isolated and characterised from a marine actinobacterium Streptomyces sp. MVCS6 from Versova coast |
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Authors: | P Sivaperumal K Kamala R Rajaram |
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Institution: | 1. Central Institute of Fisheries Education, ICAR-Deemed University, Off Yari Road, Versova, Andheri (W), Mumbai 400 061, Maharashtra, India;2. Department of Marine Science, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India;3. Department of Marine Science, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India |
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Abstract: | The melanin pigment produced from Streptomyces sp., MVCS6 was isolated and dihydroxyphenyalanine (DOPA) melanin compound was biochemically identified and spectroscopically characterised (ultraviolet and FT-IR). DOPA melanin showed a promising activity as an antibacterial natural product against 12 pathogenic bacteria from hospital isolations, particularly, against Pseudomonas aeruginosa RMMH7 (inhibition zone of 18 ± 0.02 at 30 μg/disc, and MIC of 10 ± 0.02 μg/mL) and Vibrio parahaemolytics RMMH12 (inhibition zone of 15 mm ± 0.03 at 30 μg/disc, and MIC of 14 ± 0.02 μg/mL). Moreover, in vitro evaluation of reducing power (Ascorbic Acid Equivalent (160 μg/mL)), DPPH radical-scavenging (89%), NO-scavenging (72%) and lipid peroxidation activities (89.6%) were determined. Cytotoxicity of DOPA melanin against cervical cancer cell line showed a dose–response activity, and IC50 value was found to be 300 μg/mL. These results would open the way to propose Streptomyces sp. MVCS6 as a promising source of bioactive eumelanin with therapeutic potential in medicine. |
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Keywords: | melanin FT-IR antibacterial antioxidant cytotoxicity activity |
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