A new antimicrobial and radical-scavenging glycoside from Paullinia pinnata var. cameroonensis |
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| Authors: | Paul-Keilah Lunga Xu-Jie Qin Xing-Wei Yang Jules-Roger Kuiate |
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| Institution: | 1. Laboratory of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, P.R. China;3. Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, P.R. China;5. University of Chinese Academy of Sciences, Beijing 100049, P.R. China |
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| Abstract: | A new glycoside, pinnatoside A (1), together with two known compounds (2 and 3), were isolated from the stems of Paullinia pinnata. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical methods. Compound 1 showed significant antibacterial activity with a minimum inhibitory concentration (MIC) value of 1.56 μg/mL against Escherichia coli, and 2 displayed significant antibacterial activity with a MIC value of 1.56 μg/mL against Enterobacter aerogenes and E. coli. Equally, compound 1 exhibited the best radical-scavenging activity (RSa50 = 25.07 ± 0.49 μg/mL). |
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| Keywords: | Paullinia pinnata pinnatoside A antimicrobial activity radical-scavenging activity |
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