In vivo gastroprotective effect of xyloccensin-E and xyloccensin-I from Xylocarpus molluccensis in rats |
| |
Authors: | Vijai Lakshmi Vaibhav Mishra Gautam Palit |
| |
Institution: | 1. Division of Medicinal and Process Chemistry, Research Institute, Lucknow226001, UP, India;2. Division of Pharmacology, Central Drug Research Institute, Lucknow226001, UP, India |
| |
Abstract: | Anti-ulcer activities of xyloccensin-E and xyloccensin-I were investigated in various ulcer models in Sprague-Dawley rats. The effects and the mechanism of action of both compounds for anti-secretory and cytoprotective activities were also studied. Both these active molecules improved the depleted levels of mucin and consequently inhibited the formation of erosions in a pyloric ligated ulcer model. Furthermore, xyloccensin-E and xyloccensin-I inhibited H+K+-ATPase activity in vitro confirming their anti-secretory activity. In conclusion, xyloccensin-E and xyloccensin-I were found to possess anti-ulcerogenic activity which might be due to their anti-secretory activity and subsequent strengthening of the defensive mechanism. |
| |
Keywords: | gastric ulcer proton pump xyloccensin E and xyloccensin I |
|
|