Unprecedented new nonadecyl para-hydroperoxycinnamate isolated from Erythrina excelsa and its cytotoxic activity |
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| Authors: | Guy M.N. Kwamou Victor Kuete Anaelle A.K. Wandja Simplice B. Tankeo |
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| Affiliation: | 1. Department of Organic Chemistry, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon;2. Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128Mainz, Germany |
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| Abstract: | A new unprecedented cinnamate derivative (1) was obtained from Erythrina excelsa (Leguminosae) and identified as nonadecyl para-hydroperoxycinnamate. This compound was isolated together with three known compounds, namely lupeol (2), mixture of sitosterol and stigmasterol (3), and isoneorautenol (4). Their structures were established on the basis of NMR and mass spectroscopic data in conjunction with those reported in the literature. Compound 1 was evaluated for its capability of inhibiting cancer cell lines and growth of a panel of microbial strains. It turned out that 1 is moderately to significantly cytotoxic against six cancer cell lines and shows weak to no antimicrobial activity. |
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| Keywords: | anticancer activity drug resistance para-hydroperoxycinnamate Fabaceae |
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