Two new triterpenoids from Nauclea officinalis |
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| Authors: | Hai-Yang Wang Ke Liu Ru-Xia Wang San-Hai Qin Feng-Ling Wang |
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| Affiliation: | 1. Key Laboratory of Rare and Uncommon Diseases, Institute of Materia Medica, Shandong Academy of Medical Sciences, Ji'nan, Shandong 250062, PR China;2. Suzhou Reina pharmaceutical R&3. D Co., Ltd, Suzhou, Jiangsu 215123, PR China;4. Shandong Academy of Medical Sciences Graduate Education Center, Ji'nan, Shandong 250062, PR China |
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| Abstract: | Two new triterpenoids and three 27-nor-triterpenoids were isolated from the stems (with bark) of Nauclea officinalis. Their structures were identified to be 2β,3β,19α,23-tetrahydroxy-urs-12-en-28-oic acid (1), 2β,3β,19α,23-tetrahydroxy-urs-12-en-28-O-[β-d-glucopyranosyl (1-2)-β-d-glucopyranosyl] ester (2), pyrocincholic acid 3β-O-α-l-rhamnopyranoside (3), pyrocincholic acid 3β-O-α-l-rhamnopyranosy1-28-O-β-d-glucopyranosyl ester (4), pyrocincholic acid 3β-O-α-l-rhamnopyranosy1-28-O-β-d-glucopyranosyl-(1-6)-β-d-glucopyranosyl ester (5) by spectroscopic methods including 1D, 2D NMR and HR-MS analyses. The cytotoxic activity of 1–5 against lung cancer A-549 cells was also investigated. |
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| Keywords: | Rubiaceae Nauclea officinalis triterpenoid pyrocincholic acid |
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