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Two new dimeric naphthoquinones with neuraminidase inhibitory activity from Lithospermum erythrorhizon |
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| Authors: | Yanqin Yang Dapeng Zhao Kailong Yuan Guojun Zhou Yu Wang Yanmeng Xiao |
| Institution: | 1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun130022, P.R. China;2. Technology Center, China Tobacco Zhejiang Industrial CO., LTD, Hangzhou310024, P.R. China;3. Changchun Institute of Biological Products CO., LTD, Changchun130062, P.R. China;4. Technology Center, China Tobacco Zhejiang Industrial CO., LTD, Hangzhou310024, P.R. China |
| Abstract: | The crude methanol extract of roots of Lithospermum erythrorhizon was subjected to successive chromatographic fractionation which afforded two new dimeric naphthoquinone derivatives shikometabolin E (2) and shikometabolin F (3) as well as one known compound shikometabolin A (1). The structures of compounds 1–3 were elucidated by using UV, MS, 1D and 2D NMR spectroscopic analysis. The two new dimeric naphthoquinone derivatives showed significant neuraminidase inhibitory activities. |
| Keywords: | Lithospermum erythrorhizon dimeric naphthoquinone neuraminidase inhibitory |