| Asymmetric Hydrogenation Synthesis of (S)-(+)-2-(6′-methoxyl-2-naphthyl) propionic Acid by Cinchona Modified Pd(0)-α-FeOOH Catalyst |
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| 作者姓名： | Hong Zhu MA Bo WANG* College of Chemistry and materials science ShaanXi Normal University Xian |
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| 作者单位： | Hong Zhu MA，Bo WANG* College of Chemistry and materials science，ShaanXi Normal University，Xian 710062 |
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| 摘 要： | During the past decades enormous progress was made in asymmetric catalytic synthesis, an well-known example is BINAP1, the chiral hydrogenation synthesis of S-(+)-naproxen catalyzed by BINAP-Ru dicarboxylate complexes provides excellent enantioselectivity (up to 99% ee) and good chemical yield (92%), however the pressures is relatively high (135-150 atm) and the (S)-BINAP-Ru(III) complex is very expensive. This problem may present a practical limitation. In recent years new methodolo…
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| 关 键 词： | Pd(0)-α-FeOOH |
Asymmetric Hydrogenation Synthesis of (S)-(+)-2-(6′-methoxyl- 2-naphthyl) propionic Acid by Cinchona Modified Pd(0)-α-FeOOH Catalyst |
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| Hong Zhu MA,Bo WANG* College of Chemistry and materials science,ShaanXi Normal University,Xian .Asymmetric Hydrogenation Synthesis of (S)-(+)-2-(6′-methoxyl- 2-naphthyl) propionic Acid by Cinchona Modified Pd(0)-α-FeOOH Catalyst[J].Chinese Chemical Letters,2003,14(11). |
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| Authors: | Hong Zhu MA Bo WANG |
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| Abstract: | Asymmetric hydrogenation of (6-methoxyl-2-naphthyl)-2-acrylic acid catalyzed by cinchona modified Pd(0)-α-FeOOH was reported and ee's of (S)-(+)-2-(6′-methoxyl-2-naphthyl) propionic acid ((S)-(+)-naproxen) up to 98% was achieved firstly. |
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| Keywords: | Asymmetric hydrogenation catalyze cinchona Pd(0)-a-FeOOH (S)-(+)-naproxen |
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