Metal-free N-h insertions of donor/acceptor carbenes |
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Authors: | Stephanie R Hansen Jillian E Spangler Jørn H Hansen Huw M L Davies |
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Affiliation: | Emory University , Department of Chemistry, 1515 Dickey Drive, Atlanta, Georgia 30322, United States. |
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Abstract: | Synthetically useful transformations arise from the thermal decomposition of aryldiazoacetates in the presence of primary and secondary amines without the use of a metal catalyst. Thermally generated, free donor/acceptor carbenes directly undergo N-H insertion with amines through selective aza-ylide formation to afford a variety of α-amino esters in 53-96% yields. |
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