Novel diphenylmethyl-Derived Amide Protecting Group for Efficient Liquid-Phase Peptide Synthesis: AJIPHASE |
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Authors: | Daisuke Takahashi Tatsuya Yano Tatsuya Fukui |
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Institution: | Research Institute for Bioscience Products and Fine Chemicals, AJINOMOTO Co., Inc. , 1730 Hinaga Yokkaichi Mie 510-0885, Japan. |
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Abstract: | An efficient method for the synthesis of peptides bearing an amide at the C-terminal is described. This method involves the attachment of a C-terminal protecting group bearing long aliphatic chains, followed by the repetition of simple reaction and precipitation steps with the combined advantages of liquid-phase peptide synthesis (LPPS) and solid-phase peptide synthesis (SPPS). Using this method, a hydrophobic peptide was successfully synthesized in good yield and high purity, which cannot be obtained satisfactorily by SPPS. |
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