Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter

Authors:	Natasha Thorne Min Shen Wendy A Lea Anton Simeonov Scott Lovell Douglas S Auld James Inglese

Institution:	National Center for Advancing Translational Sciences, Bethesda, MD 20892-3370, USA.

Abstract:	Download : Download high-res image (480KB) Download : Download full-size image Highlights? A representative small molecule library contains 12% firefly luciferase inhibitors ? Competitive, noncompetitive, uncompetitive, and MAI inhibitors were identified ? For FLuc-RGAs 65% of FLuc inhibitors with known MOIs increased the luminescence signal ? Methods to identify FLuc inhibitors that interfere with assay results are described

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