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Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

Authors:	Yu Wang Lance Davidow Anthony C Arvanites Joel Blanchard Kelvin Lam Ke Xu Vatsal Oza Jin Woo Yoo Jessica M Y Ng Tom Curran Lee L Rubin Andrew P McMahon

Institution:	Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract:	Download : Download high-res image (140KB) Download : Download full-size image Highlights? Screened compound libraries for modulation of Smo movement to the primary cilium ? Identified glucocorticoids inducing Smo ciliary accumulation without activation ? They sensitize cells to Hh input and potentially modify the efficacy of Smo antagonists ? Identified a glucocorticoid inhibitor effective in inhibiting drug-resistant Smo mutants

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