Fluoro-ketones. I reactions of hydrocarbon grignards with perfluoroalkylacid fluorides

The reaction between Grignard reagents and perfluoroacid fluorides provides a convenient synthesis procedure for ketones R_fOR_fC(O)R′, where R_fOR_f is perfluoroalkylether group and R' is either an aromatic or aliphatic group. Reaction temperature is an important factor in producing higher yields of ketones. Meta and para-bromophenyl Grignard reagents, which thus far have not been prepared as pure mono Grignards, present secondary competing reactions which detract from their synthetic utility.