Comparative study between chloramine-T and iodogen to prepare radioiodinated etodolac for inflammation imaging |
| |
Authors: | Email author" target="_blank">H?HussienEmail author A?A?Goud A?M?Amin R?EL-Sheikh U?Seddik |
| |
Institution: | (1) Cyclotron Project, Nuclear Research Center, Atomic Energy Authority, P.O. Box. 13759, Cairo, Egypt;(2) Labeled Compound Department, Hot Labs Center, Atomic Energy Authority, Cairo, Egypt;(3) Faculty of Science, Zagazig University, Zagazig, Egypt |
| |
Abstract: | This study describes a fast and efficient method for radiolabeling of etodolac with iodine-125 125I], where both chloramine-T and iodogen were used as oxidizing agents. The labeling reaction was carried out via electrophilic
substitution of hydrogen atom with the iodonium cation I+. The labeling yield was found to be influenced by different factors such as drug concentration, pH of the reaction mixtures,
different oxidizing agents, reaction time, temperature and different organic media. The radiochemical yield (RCY) was determined
by TLC system using methylene chloride:ethyl acetate (3:7 v/v) as a developing solvent and by electrophoresis using cellulose
acetate moistened with 0.02 M phosphate buffer pH 7. The maximum radiochemical yield of 125I]Etodolac (87.7%) was obtained. Labeled etodolac shows a good localization in inflamed muscle. It excretes mainly via kidney
and to some via liver. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|