CHLORPROMAZINE PHOTOSENSITIZATION–II. FAILURE TO DETECT ANY EVIDENCE FOR INVOLVEMENT OF DNA DAMAGE IN THE PHOTODYNAMIC KILLING OF ESCHERICHIA COLI IN THE PRESENCE OF CHLORPROMAZINE |
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| Authors: | Itsuro Matsuo Muneo Ohkido Hitoshi Fujita Kenshi Suzuki |
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| Institution: | *Department of Dermatology, Tokai University School of Medicine, Isehara Kanagawa, 259–11, Japan;?Department of Molecular Biology, Tokai University School of Medicine, Isehara Kanagawa, 259–11, Japan |
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| Abstract: | Abstract— When a suspension of Escherichia coli was irradiated with near-UV light in the presence of chlorpromazine (at a concentration below a cytotoxic level), the cells were killed. Efficiency of the photodynamic killing was not influenced by the deficiency of the uvrA gene or the recA gene. Neither phenotypic reversion of E. coli Hs30R (arginine auxotroph) nor induction of lambda prophage in lysogenic bacteria was detected after this treatment. |
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