Amine decorated 2d hexagonal and 3d cubic mesoporous silica nanoparticles: A comprehensive dissolution kinetic study in simulated and biorelevant media

Highly ordered Bexarotene (BXR) encapsulated mesoporous silica nanoparticles in particular bare and amine functionalized MCM-41 and MCM-48 were designed employing a novel impregnation solvent evaporation strategy. The outcomes unveiled successful synthesis of mesoporous assembly having 2?D hexagonal and 3?D cubic framework for MCM-41 and MCM-48 respectively withholding large surface area, optimum pore size, pore volume along with uniform particle size distribution. Additionally, SXRD and TEM findings divulged retention of characteristic mesoporous features regardless of surface modification and drug incorporation. Eventually the release profile and release kinetics results in different dissolution media demonstrated complete drug release in simulated intestinal fluid (SIF) within 75?min and 45?min from BXR-41 and BXR-48 along with 3.33 and 5 fold increment in dissolution profile. Furthermore, lack of any interaction between gelatin of hard capsule shell and amine group in presence of enzyme were justified from the indistinguishable release pattern in enzyme free and enzyme enriched SIF media. The divergent release pattern in fed and fasted state condition having a higher release in former media strongly directs towards taking medicine after meal. Finally the release kinetics study exhibited Weibull and Higuchi model as a best fit models for bare and amine coated BXR nanoparticles respectively.