Phase evolution,structural characteristics and mechanism of vesicle formation from a synthetic amphiphile: Controlled morphology by tuning solution phase parameters |
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| Authors: | Ramakanth Illa |
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| Affiliation: | Department of Chemistry, Rajiv Gandhi University of Knowledge Technologies, IIIT Nuzvid, Nuzvid, India |
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| Abstract: | We report herein, the aggregation behavior of 3, 4-di(dodecyloxy)benzoic acid-4-hydroxy phenyl ester (DDBE), a synthetic amphiphile and a true non-ionic surfactant system as per the geometrical considerations. The true surfactant nature of the system stems from its hydrophilic-lipophilic-balance (HLB?=?4.7), comparable to that of Span-60, also a true non-ionic surfactant. This compound undergoes spontaneous vesicle formation in THF:water binary solvent mixtures which further underwent fission at lower DDBE concentrations and fusion at higher concentrations, leading to giant vesicles of the order of 3000?nm. These vesicles are sensitive to the polarity of their environment. The predominant mode of interaction as observed from the molecular dynamics simulations were found to be π-π stacking with the phenyl rings of the molecule. Further, the system, upon complete extraction into water, formed spherical aggregates of size 50?nm based on the good solvent-poor solvent combination as the necessary condition for the vesicle formation.GRAPHICAL ABSTRACT | |
| Keywords: | Bilayer vesicle non-ionic surfactant binary solvent mixtures molecular dynamics simulations unilamellar vesicle vesicle fission and fusion |
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