Tannic acid-coated zeolite Y nanoparticles as novel drug nanocarrier with controlled release behavior and anti-protozoan activity against Trichomonas gallinae |
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| Authors: | Hosna Rezaee Ali Nikpay Maryam Soltani |
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| Institution: | 1. Department of Chemical Engineering, Babol Noshirvani University of Technolgy, Babol, Iran;2. Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran;3. Faculty of Veterinary Medicine, Urmia University, Urmia, Iran |
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| Abstract: | In this study, a pH-sensitive drug release system was prepared by zeolite Y nanoparticles and tannic acid. Zeolite Y nanoparticles were synthesized via hydrothermal synthesis of colloidal suspensions and after that, were coated with tannic acid. In order to evaluate its performance, metronidazole as an anti-protozoan drug was loaded into nanocarriers via immersing method to study the in-vitro drug delivery behavior. This nanocomposite carriers represented pH-sensitive behavior and had more and faster release in acidic medium. In-vitro effects of metronidazole-loaded nanoparticles was measured against Trichomonas gallinae trophozoites in Trypticase Yeast extract Maltose medium. The results suggested that metronidazole-loaded and tannic acid-modified zeolite Y nanoparticles could be a potential anti-trichomonal agent. |
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| Keywords: | Drug delivery metronidazole tannic acid trichomonas gallinae zeolite Y |
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