Determinations of the inclusion complex between gossypol and beta-cyclodextrin |
| |
Authors: | Shen Ying-lin Ying Wei Yang Sheng-hua Wu Long-min |
| |
Affiliation: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. |
| |
Abstract: | Features of the inclusion complex between gossypol (Gos) and beta-cyclodextrin (CD), such as its aqueous solubility, association constant, characteristics in the solid state and crystalline morphology, as well as the stoichiometry of this complex have been determined. The phase-solubility diagram drawn using UV detections belongs to an AN-type. Fluorescence detection and calculation with the modified Benesi-Hidebrond equation provide an 1:2 stoichiometry for the complex. Its apparent stability constant has been determined to be 3,203 M(-1) by fluorescence technique and confirmed by the calculation from UV spectroscopy. X-ray powder diffractions (XRD) and Scanning Electron Microscopy (SEM) observations showed a clear difference in the crystal morphology of the complex from those of both Gos and beta-CD. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|