An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices |
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Authors: | Chen Robert J Choi Hee Cheul Bangsaruntip Sarunya Yenilmez Erhan Tang Xiaowu Wang Qian Chang Ying-Lan Dai Hongjie |
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Affiliation: | Department of Chemistry, Stanford University, Stanford, California 94305, USA. |
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Abstract: | It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenon that can be exploited for label-free detection of biomolecules with a high potential for miniaturization. This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selected components of the devices from protein adsorption, self-assembled monolayers (SAMs) of methoxy(poly(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants on the nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the electronic biosensing signal than adsorption solely along the exposed lengths of the nanotubes. |
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