Goniodilactone and gomoheptenolactone,two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis |
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| Authors: | Jiu Xiang Zhua Dong Lei Yub Wen Hua Huanga Lan Suna Yang Lvc Qi Tai Zhengc Kuo Hsiung Leeb Jing Guang Yua a |
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| Affiliation: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China ; Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, USA ; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI50S in the range of 1.29-4.56μg/mL. |
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| Keywords: | Goniothalamus cheliensis Goniodilactone Gonioheptenolactone Cytotoxic activity Styryllactones |
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