Fluorination of alcohols and diols with a novel fluorous deoxy-fluorination reagent |
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Authors: | Tsukasa Furuya |
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Affiliation: | Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan |
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Abstract: | We prepared a novel fluorous deoxy-fluorination reagent N,N-diethyl-α,α-difluoro-[3,5-bis(1H,1H,2H,2H-perfluorodecyl)benzyl]amine (1b) from 3,5-diiodobenzoic acid (3b) via N,N-diethyl-3,5-bis(1H,1H,2H,2H-perfluorodecyl)benzamide (2b) in four steps and used it for the fluorination of alcohols and diols. After the fluorination reactions, the isolation of the products and recovery of 2b was performed by extraction with a fluorous/organic solvent system. |
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Keywords: | Fluorous fluorination reagent Deoxy-fluorination reaction N,N-Diethyl-α,α-difluoro-[3,5-bis(1H,1H,2H,2H-perfluorodecyl)benzyl]amine |
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