Pentafluorobenzaldehyde and its utilizing in organic synthesis |
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Authors: | Andrej Pa?itný ,Tomá &scaron Sol?á n,Daniel Vé gh |
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Affiliation: | Institute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia |
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Abstract: | Over the past 50 years, pentafluorobenzaldehyde has received much attention due to its unique chemical and physical properties as well as its real or potential applications in chemistry of porphyrines, additives, drug delivery and in analytical chemistry. Pentafluorobenzaldehyde is multifunctional aromatic compound containing five atoms of fluorine and one aldehydic function. That is why it can provide nucleophilic substitutions of all or some atoms of fluorine, nucleophilic additions of aldehydic function, “haloform reaction” and some cyclization reactions. This year, it is being the 50th year, since the first synthesis of this compound was published. |
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Keywords: | Pentafluorobenzaldehyde Multifunctional molecule Physical and chemical properties Biological properties Toxicity of pentafluorobenzaldehyde Nucleophilic substitution Nucleophilic addition of aldehydic function &ldquo Haloform reaction&rdquo Cyclization reactions |
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