Development of a cholesterol-conjugated fluorescent sensor for site-specific detection of zinc ion at the plasma membrane |
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| Authors: | Iyoshi Shohei Taki Masayasu Yamamoto Yukio |
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| Institution: | Graduate School of Human and Environmental Studies, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. |
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| Abstract: | A cholesterol-conjugated fluorescence Zn(2+) sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn(2+) sensor to the cell membrane, allowing the sensor to probe changes in the Zn(2+) concentration in a localized area of the cell. |
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