New observation on a class of old reactions: Chemoselectivity for the solvent-free reaction of aromatic aldehydes with alkylketones catalyzed by a double-component inorganic base system |
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Authors: | ZiXing Shan XinXiang Luo Lin Hu XiaoYun Hu |
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Institution: | 1. Department of Chemistry, Wuhan University, Wuhan, 430072, China 2. Department of Chemistry and Environment Engineering, Hunan City University, Yiyang, 413049, China
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Abstract: | Solvent-free reactions of aromatic aldehydes with three representative ketones, including acetophenone, acetone and cyclohexanone, have been examined under the catalysis of a low-cost inorganic base system consisting of NaOH and K2CO3. It was found that the chemoselectivity of the reactions is in close relationship with the composition of the reactants and the doublecomponent catalyst. Under the optimized experimental conditions, 1,2,3,4,5-pentasubstituted cyclohexanols, α,β-unsaturated ketones and Claisen-Schmidt bicondensation products were obtained in high yields. Two Kostanecki’s triketones were separated, The composition and structure were affirmed by X-ray crystallographic analysis. |
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