| 肟醚噻二唑硫醚化合物的合成及其抗肿瘤活性 |
| |
| 引用本文： | 张耀洲,肖颖,杨俊杰,胡国强. 肟醚噻二唑硫醚化合物的合成及其抗肿瘤活性[J]. 应用化学, 2013, 30(4): 383-388. DOI: 10.3724/SP.J.1095.2013.20259 |
| |
| 作者姓名： | 张耀洲 肖颖 杨俊杰 胡国强 |
| |
| 作者单位： | (1.信阳农业高等专科学校生物技术系 信阳 464000；2.河南大学化学生物学研究所 开封 475001) |
| |
| 基金项目： | 国家自然科学基金资助项目 |
| |
| 摘 要： | 将2-巯基-5-取代基-1,3,4-噻二唑经与β-氯苯丙酮取代、盐酸羟胺肟化和氯甲基噁二唑醚化，合成了6种3-(5-取代基-1,3,4-噻二唑-2-硫代基)-1-苯基丙酮-O-(5-苯基-1,3,4-噁二唑-2-甲基)肟醚化合物(4a~4f)，用1H NMR、IR、MS和元素分析表征了其结构。 用MTT法测试了6种目标化合物对人黑色素瘤细胞株B16、人白血病细胞株HL60和人肝癌细胞株SMMC-7721的体外细胞毒活性。 测试结果表明，部分化合物对3种癌细胞具有潜在的体外生长抑制活性。
|
| 关 键 词： | 噻二唑 噁二唑 肟醚 抗肿瘤活性 |
| 收稿时间： | 2012-06-11 |
| 修稿时间： | 2012-08-11 |
Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers |
| |
| ZHANG Yaozhou , XIAO Ying , YANG Junjie , HU Guoqiang. Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers[J]. Chinese Journal of Applied Chemistry, 2013, 30(4): 383-388. DOI: 10.3724/SP.J.1095.2013.20259 |
| |
| Authors: | ZHANG Yaozhou XIAO Ying YANG Junjie HU Guoqiang |
| |
| Affiliation: | (1.Department of Biotechnology,Xinyang Agricultural College,Xinyang 464000,China；;2.Institute of Chemistry & Biology,Henan University,Kaifeng 475001,China) |
| |
| Abstract: | The synthesis of six oxime ether thiadiazolylthioether compounds(4a~4f) involved a β-chloropropiophenone substitution on 2-mercapto-5-substituded-1,3,4-thiadiazole, oximation with hydroxylamine and etherification with 5-chloromethyl-2-phenyl-1,3,4-oxadiazole. Their structures were characterized by 1H NMR, IR, MS and elemental analysis. The in vitro antitumor activities of the six compounds to B16, HL60 and SMMC-7721 cancer cell strains were evaluated by MTT assay. The preliminary results showed that some of them showed potential antiproliferation activity. |
| |
| Keywords: | thiadiazole oxadiazole oxime ether antitumor activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《应用化学》浏览原始摘要信息 |
|
点击此处可从《应用化学》下载全文 |
|
