Synthesis of imidazolo analogues of the oxidation-reduction cofactor pyrroloquinoline quinone (PQQ) |
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Authors: | Fouchard David M D Tillekeratne L M V Hudson Richard A |
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Institution: | Department of Medicinal and Biological Chemistry, College of Arts and Sciences, University of Toledo, Toledo, Ohio 43606, USA. |
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Abstract: | Parallel syntheses of 2-hydro-, 2-methyl-, and 2-methoxycarbonylimidazo-7,9-dimethoxycarbonyl analogues of the oxidation-reduction cofactor pyrroloquinoline quinone 4,5-dihydro-4,5-dioxo-1H-pyrrolo2,3-f]quinoline-2,7,9-tricarboxylic acid] have been developed. The properties of the imidazolo analogues in relation to the corresponding pyrrole analogues will be important in assessing the origins of catalysis and biological activity in the cofactor, which has recently been shown to be a vitamin. |
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