Spin trapping of superoxide in the presence of beta-cyclodextrins |
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| Authors: | Karoui Hakim Rockenbauer Antal Pietri Sylvie Tordo Paul |
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| Institution: | UMR 6517 CNRS and Universités d'Aix-Marseille 1 and 3, Faculté des Sciences de Saint Jér?me, 13397 Marseille, France. hakim@srepir1.univ-mrs.fr |
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| Abstract: | The trapping of superoxide anion with DMPO and DEPMPO has been carried out in the presence of a methylated beta-cyclodextrin, Me-beta-CD; inclusion of the spin adducts in the cavity of Me-beta-CD resulted in a seven-fold increase of their half-life (t1/2 = 96 min for DEPMPO-superoxide spin adduct) and in their protection towards glutathione peroxidase (Gpx) and also ascrobate anion in the case of DEPMPO. |
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