Versatile enantiocontrolled synthesis of (+)-fostriecin |
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Authors: | Esumi Tomoyuki Okamoto Nanako Hatakeyama Susumi |
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Affiliation: | Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan. susumi@net.nagasaki-u.ac.jp |
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Abstract: | Fostriecin, a potent protein phosphatase inhibitor and antitumor agent, has been enantioselectively synthesized in naturally occurring form via a versatile route, which also allows one to secure all possible stereoisomeres of the C1-C13 fragment including the C11 stereocenter and the geometry of the delta 12-double bond. |
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