Decarbonylative approach to the synthesis of enamides from amino acids: stereoselective synthesis of the (Z)-aminovinyl-D-cysteine unit of mersacidin |
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| Authors: | García-Reynaga Pablo Carrillo Angela K VanNieuwenhze Michael S |
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| Institution: | Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47505, USA. |
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| Abstract: | The Pd- and Ni-promoted decarbonylation of amino acid thioesters proceeds smoothly to yield enamides. The synthesis of the (S)-(Z)-AviMeCys subunit of mersacidin, an MRSA-active lantibiotic, via this approach, is described. |
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