Circular permutation of the starch-binding domain: inversion of ligand selectivity with increased affinity |
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| Authors: | Stephen Preyesh Tseng Kai-Li Liu Yu-Nan Lyu Ping-Chiang |
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| Institution: | Institute of Bioinformatics and Structural Biology, National Tsing Hua University, No. 101, Sec. 2, Kuang Fu Rd, Hsinchu, 30013, Taiwan ROC. |
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| Abstract: | Proteins containing starch-binding domains (SBDs) are used in a variety of scientific and technological applications. A circularly permutated SBD (CP90) with improved affinity and selectivity toward longer-chain carbohydrates was synthesized, suggesting that a new starch-binding protein may be developed for specific scientific and industrial applications. |
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