Model system for cell adhesion mediated by weak carbohydrate-carbohydrate interactions |
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Authors: | Lorenz Bärbel Álvarez de Cienfuegos Luis Oelkers Marieelen Kriemen Ella Brand Christian Stephan Milena Sunnick Eva Yüksel Deniz Kalsani Venkateshwarlu Kumar Krishna Werz Daniel B Janshoff Andreas |
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Affiliation: | Institute of Physical Chemistry, University of G?ttingen, Tammannstrasse 6, 37077 G?ttingen, Germany. |
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Abstract: | The multivalent carbohydrate-carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell-cell contacts.The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. A deterministic model was used to estimate the basic energy landscape and number of participating bonds in the contact zone. |
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