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| 新型吡唑Schiff碱及金属配合物的合成和抑菌活性 | |
| 引用本文： | 程青芳,许兴友,王启发,张莉,林俏,张君磊,杨绪杰.新型吡唑Schiff碱及金属配合物的合成和抑菌活性[J].有机化学,2009,29(9):1387-1391. |
| 作者姓名： | 程青芳 许兴友 王启发 张莉 林俏 张君磊 杨绪杰 |
| 作者单位： | 1. 淮海工学院江苏省海洋生物技术重点实验室,连云港,222005;南京理工大学材料化学实验室,南京,210094 2. 南京理工大学材料化学实验室,南京,210094;淮海工学院化学工程系,连云港,222005 3. 淮海工学院江苏省海洋生物技术重点实验室,连云港,222005 4. 淮海工学院化学工程系,连云港,222005 5. 南京理工大学材料化学实验室,南京,210094 |
| 基金项目： | 江苏省教育厅重大基础研究基金，江苏省海洋生物技术重点建设实验室基金(No.2007HS009) 和连云港市科技攻关项目基金 |
| 摘 要： | 以3-氨基-4-氰基吡唑和芳醛为原料合成了10个新型吡唑Schiff碱及铜(II)、镍(II)、锌(II)、钴(II) 4个金属配合物. 用元素分析, IR, 1H NMR及单晶解析表征了Schiff碱及金属配合物的结构. 测定了Schiff碱及金属配合物对金黄色葡萄球菌、大肠杆菌、枯草杆菌和绿脓杆菌的抑菌活性. 生物活性研究表明, Schiff碱及金属配合物对金黄色葡萄球菌、大肠杆菌和绿脓杆菌都有较好的抑菌效果, 其中铜(II)和锌(II)配合物对金黄色葡萄球菌和大肠杆菌的抑菌活性最好. |
| 关 键 词： | 吡唑Schiff碱 3-氨基-4-氰基吡唑 金属配合物 抑菌活性 |
| 收稿时间： | 2008-12-17 |
| 修稿时间： | 2009-2-24 |
Synthesis and Antibacterial Activities of Novel Pyrazole Schiff Bases and Metal Complexes |
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| Cheng Qingfang,Xu Xingyou,Wang Qifa,Zhang Li,Lin Qiao,Zhang Junlei,Yang Xujie.Synthesis and Antibacterial Activities of Novel Pyrazole Schiff Bases and Metal Complexes[J].Chinese Journal of Organic Chemistry,2009,29(9):1387-1391. | |
| Authors: | Cheng Qingfang Xu Xingyou Wang Qifa Zhang Li Lin Qiao Zhang Junlei Yang Xujie |
| Institution: | ( Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology, Lianyungang 222005) ( Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094) ( Department of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005) |
| Abstract: | Ten novel pyrazole Schiff bases derived from 3-amino-4-cyanopyrazole and aromatic aldehydes, and four metal complexes of Cu(II), Ni(II), Zn(II), and Co(II) have been synthesized and characterized by elemental analysis, IR, 1H NMR, and X-ray analysis. The antibacterial activities have been screened for these compounds against four bacteria: Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. The primary biological activity assay showed that all products exhibited medium to high antibacterial activities against Staphylococcus aureus, Escherichia coli and Pseudomonas aerugi-nosa. Cu(II) and Zn(II) complexes had the most intense antibacterial activities against Staphylococcus aureus and Escherichia coli. |
| Keywords: | pyrazole Schiff base 3-amino-4-cyanopyrazole metal complex antibacterial activity |
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