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A simple and efficient synthesis of the valsartan
Authors:Chen Xi Zhang  Guo Jun Zheng  Fu Qiang Bi  Yu Lin Li
Institution:State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China. Received 11 December 2007
Abstract:Valsartan 1,one of the most important agents used in antihypertensive therapy today,was synthesized starting from L-valin methyl ester hydrochloride 2 through four steps in an overall yield of 60%.The key step involves the palladium-catalyzed SuzuKi coupling.This method overcomes many of the drawbacks associated with the previously reported syntheses and is more suitable for industrial production.
Keywords:Valsartan  Antihypertensive  L-Valin methyl ester hydrochloride  Synthesis  Suzuki coupling
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