Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity** |
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| Authors: | Guénin Hervé Floch Loisel Yaouanc Clément Férec des Abbayes H |
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| Affiliation: | UMR CNRS 6521, Université de Bretagne Occidentale Département de Chimie 6, avenue Le Gorgeu, BP 809, 29285 Brest Cedex (France). |
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| Abstract: | Replacing the ammonium polar head in cationic lipids 1 (A=N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA. |
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