PHOTOCYCLOADDITION OF ACETONE TO URACIL AND CYTOSINE |
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| Authors: | A J Varghese |
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| Institution: | Physics Division, Ontario Cancer Institute, 500 Sherbourne St., Toronto, Canada |
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| Abstract: | Abstract— Ultraviolet irradiation (Λ > 280 nm) of uracil in aqueous acetone (1:1) produces cyclobutane uracil dimer and uracil-acetone addition product. The addition product is identified as an oxetane. The same product is also obtained from cytosine irradiated under the same conditions. The cytosine-acetone oxetane apparently undergoes deamination readily. Irradiation (Λ= 265 nm) of the oxetane in aqueous solution produces acetone and uracil with a quantum efficiency of 0–16. |
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